Nicotine pouches have similar toxicant levels to NRTs

Food and Chemical Toxicology

E, Bishop et al. “An approach for the extract generation and toxicological assessment of tobacco-free ‘modern’ oral nicotine pouches.” Food and Chemical Toxicology vol. 145 (2020).

This peer-reviewed study examined the effects of tobacco-free nicotine pouches, snus and cigarettes on human cell cultures.
The results showed that toxicant levels in nicotine pouches are significantly lower than in cigarettes or snus. The levels in pouches are similar to nicotine replacement therapies (NRT).
Nicotine pouches are likely to have similar or less health risks than Swedish snus, a product recognised to reduce the harm associated with tobacco smoking. Snus use is popular in Sweden, and is believed to be a contributing factor to Sweden having the lowest smoking rate in Europe.
Research has shown that snus is significantly less harmful than cigarettes. Snus – use is not associated with throat, oesophagus, stomach, pancreas, lung, or heart diseases. It additionally is not linked to stroke, and the risk of using snus is approximately 1% that of smoking.
Nicotine pouches that do not contain tobacco may further reduce the risk to consumers compared to snus.